Reacción #5013

Ecuación de reacción

1-(4-aminobutyl)-4-(2-pyrimidinyl)piperazine

dl-camphoric anhydride

→

title compound

Rendimiento 17.0%

Racemic 3-(4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl)-1,8, 8-trimethyl-3-azabicyclo[3.2.1]octan-2,4-dione

Rendimiento 17.0%

Condiciones de reacción

Procedimiento

The title compound was prepared from 2.47 g (10.4 mmol) of 1-(4-aminobutyl)-4-(2-pyrimidinyl)piperazine and 1.89 g (10.3 mmol) of dl-camphoric anhydride, substantially according to the procedure of Example 1. This afforded 0.7 g of product, mp 94°-97° C. (17% yield).

Fuente