Reacción #501282

Ecuación de reacción

2-(2,6-difluorophenyl)propan-2-ol

hydrazoic acid

trifluoroacetic acid

→

2-(2,6-difluorophenyl)-2-azidopropane

Disolventes

hexane

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed with water
2. 2
   Secadowith sodium bicarbonate until free of acid and dried over sodium sulfate
3. 3
   OtroThe solvent is removed by evaporation
4. 4
   workup.DISTILLATIONthe residue is distilled

Procedimiento

20.6 g (120 millimoles) of 2-(2,6-difluorophenyl)propan-2-ol are dissolved in 300 ml of hydrazoic acid solution (1N, in benzene) and 22.8 g (200 millimoles) of trifluoroacetic acid are added to this solution. After 24 hours at room temperature, the reaction solution is diluted with 500 ml of hexane, washed with water and then with sodium bicarbonate until free of acid and dried over sodium sulfate. The solvent is removed by evaporation and the residue is distilled, affording 2-(2,6-difluorophenyl)-2-azidopropane of bp15 =85°-87° C.

Fuente