Reacción #501

Ecuación de reacción

COC(=O)c1cc(Br)ccc1I

C1COCCN1

→

COC(=O)c1cc(Br)ccc1N

Rendimiento 17.9%

Disolventes

COCCOC

Condiciones de reacción

Procedimiento

To a solution of methyl 5-bromo-2-iodobenzoate (2.1 g, 6.16 mmol) in DME (15 mL) were morpholine (0.593 mL, 6.78 mmol), rac-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl (0.384 g, 0.62 mmol), Palladium acetate (0.138 g, 0.62 mmol) and CESIUM CARBONATE (2.81 g, 8.62 mmol) added. The mixture was heated in the microwave oven for 1h. The solvent was evaporated and the crude product was added to a silica gel column, 0-25% EtOAc in heptane yielding [Products]

Fuente