Reacción #50012

Ecuación de reacción

(-)-1-(2,3,4-Trichlorophenyl)ethanesulfonic acid

racemic 4-amino-3-mercaptobutyric acid hydrochloride

→

(3R)-4-amino--3-mercaptobutyric acid (-)-1-(2,3,4-trichlorophenyl)ethanesulfonate

Rendimiento 81.5%

Disolventes

water

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.DISSOLUTIONThe mixture is dissolved at 70° C.-80° C.
2. 2
   Temperaturato cool
3. 3
   TemperaturaAfter cooling
4. 4
   Temperaturacooling for one hour
5. 5
   Filtraciónthe precipitated crystals are collected by filtration
6. 6
   Lavadowashed
7. 7
   Otrodried

Procedimiento

(-)-1-(2,3,4-Trichlorophenyl)ethanesulfonic acid (3.18 g) is dissolved in water (17.4 ml), and thereto is added aqueous solution of racemic 4-amino-3-mercaptobutyric acid hydrochloride (3.77 g)in water (24.6 ml). The mixture is dissolved at 70° C.-80° C., and allowed to cool. After cooling, the mixture is stirred under ice-cooling for one hour, and the precipitated crystals are collected by filtration, washed, and dried to give (3R)-4-amino--3-mercaptobutyric acid (-)-1-(2,3,4-trichlorophenyl)ethanesulfonate (3.8 g).

Fuente