Reacción #50004

Ecuación de reacción

Ethyl piperidine-2-carboxylate

2,4-dichloro-6-fluoro-7-isocyanato-benzothiazole

→

N-(2,4-dichloro-6-fluorobenzothiazol-7-yl)-perhydroimidazo[1,5-a]pyridine-1,3-dione

Disolventes

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was heated for 5 hours
2. 2
   Temperaturaunder reflux
3. 3
   TemperaturaAfter cooling
4. 4
   Otrothe solvent was removed in vacuo
5. 5
   Otrothe residue recrystallised several times from ethyl acetate

Procedimiento

2.6 g Ethyl piperidine-2-carboxylate was added to a solution of 4.2 g 2,4-dichloro-6-fluoro-7-isocyanato-benzothiazole in 50 ml tetrahydrofuran. The mixture was heated for 5 hours under reflux. After cooling, the solvent was removed in vacuo and the residue recrystallised several times from ethyl acetate. Yield: 2.5 g=42% of theory m.p.: 168°-170° C.

Fuente