Reacción #49960

Ecuación de reacción

3-Phenyl-l-adamantaneacetic acid

Methyl 3-bromoadamantaneacetate

Aluminum trichloride

→

methyl 3-phenyl-1-adamantaneacetate

Disolventes

benzene

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction mixture was then quenched by the addition of 0.5M phosphoric acid (1.6 L)
2. 2
   OtroThe layers were separated
3. 3
   Secadothe organic layer was dried over sodium sulfate
4. 4
   Filtraciónfiltered
5. 5
   Otroevaporated in vacuo

Procedimiento

Preparation of 3-Phenyl-l-adamantaneacetic acid, a hapten. Methyl 3-bromoadamantaneacetate (80 g) (Aldrich Chemical Co. Milwaukee Wis.) was dissolved in benzene (1.6 L) under nitrogen. Aluminum trichloride (37.12 g) was added portionwise over 75 min. at ambient temperature. The reaction mixture was then quenched by the addition of 0.5M phosphoric acid (1.6 L). The layers were separated and the organic layer was dried over sodium sulfate, filtered, and evaporated in vacuo to give methyl 3-phenyl-1-adamantaneacetate (80 g).

Fuente