Reacción #4994

Ecuación de reacción

3-ethylcarbonyl-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole

hydroxyamine hydrochloride

→

desired product

Rendimiento 85.0%

3-(alpha-hydroxyiminopropyl)-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole

Rendimiento 85.0%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was heated
2. 2
   Temperaturato reflux for 4 hours
3. 3
   OtroAfter evaporation of methanol, water
4. 4
   workup.ADDITIONwas added to the residue
5. 5
   ExtracciónThe aqueous solution was extracted with ethylacetate
6. 6
   OtroAfter evaporation of ethylacetate
7. 7
   Otrothe residue was purified by column chromatography(benzene:ether=1.1)

Procedimiento

0.9 g of 3-ethylcarbonyl-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole and 0.21 g of hydroxyamine hydrochloride were added to 10 ml of methanol. The mixture was heated to reflux for 4 hours. After evaporation of methanol, water was added to the residue. The aqueous solution was extracted with ethylacetate. After evaporation of ethylacetate, the residue was purified by column chromatography(benzene:ether=1.1) to provide 0.80 g of the desired product(yield: 85.0%).

Fuente