Reacción #49908

Ecuación de reacción

N'-t-butyl-N,N'-dibenzoylhydrazine

Methoxymethyl chloride

→

N-methoxymethyl-N'-t-butyl-N,N'-dibenzoylhydrazine

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe layers were separated
2. 2
   Lavadothe toluene layer was washed several times with water (until the water washes
3. 3
   SecadoThe toluene solution was dried over anhydrous magnesium sulfate
4. 4
   Otrothe toluene removed under vacuum

Procedimiento

N'-t-butyl-N,N'-dibenzoylhydrazine (2 g, 0.007M) was stirred at room temperature in a two phase system of toluene-50% sodium hydroxide with 100 mg of phase transfer catalyst (tetra-n-butylammonium hydrogen sulfate). Methoxymethyl chloride (1.2 g, 0.015M) was added dropwise and the mixture was stirred 3 hours. The layers were separated and the toluene layer was washed several times with water (until the water washes were neutral). The toluene solution was dried over anhydrous magnesium sulfate and the toluene removed under vacuum to afford N-methoxymethyl-N'-t-butyl-N,N'-dibenzoylhydrazine as a thick oil.

Fuente