Reacción #49907

Ecuación de reacción

HCl

allyl iodide

N'-t-butyl-N,N'-dibenzoylhydrazine

sodium hydride

→

N-allyl-N'-t-butyl-N,N'-dibenzoylhydrazine

Disolventes

water

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture was warmed to 60° C.
2. 2
   workup.STIRRINGstirred for 2 hours
3. 3
   Extracciónthe product extracted into methylene chloride (50 ml)
4. 4
   LavadoThe methylene chloride layer was washed with water (5×20 ml)
5. 5
   Secadodried over anhydrous magnesium sulfate
6. 6
   Otrothe methylene chloride removed under vacuum

Procedimiento

To a stirred solution of N'-t-butyl-N,N'-dibenzoylhydrazine (3 g, 0.011M) in DMF (30 ml) at room temperature under nitrogen was added portionwise sodium hydride (60% oil dispersion) (0.5 g, 0.012M). The mixture was stirred at room temperature for 0.5 hours, and then allyl iodide (1.8 g, 0.01M) was added dropwise. The reaction mixture was warmed to 60° C. and stirred for 2 hours. The mixture was then diluted with water (50 ml), neutralized with 10% HCl and the product extracted into methylene chloride (50 ml). The methylene chloride layer was washed with water (5×20 ml), dried over anhydrous magnesium sulfate and the methylene chloride removed under vacuum to afford N-allyl-N'-t-butyl-N,N'-dibenzoylhydrazine as an oil.

Fuente