Reacción #49813

Ecuación de reacción

(2RS)-1-(isopropoxycarbonyl)-2-methyl-1,2-dihydro-1,4,5,7-tetraazanaphthalen-3(4H)-one

(2RS)-1-(Isopropoxycarbonyl)-2-methyl-1,2-dihydro-1,4,5,7-tetraazanaphthalen-3(4H)-one

Lawesson's reagent

→

desired compound

Rendimiento 28.0%

(2RS)-1-(Isopropoxycarbonyl)-2-methyl-1,2-dihydro-1,4,5,7-tetraazanaphthalene-3(4H)-thione

Rendimiento 28.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe crude product after concentration
2. 2
   Otrowas chromatographed (silica gel; ethyl acetate/heptane=1:1)

Procedimiento

100 mg of (2RS)-1-(isopropoxycarbonyl)-2-methyl-1,2-dihydro-1,4,5,7-tetraazanaphthalen-3(4H)-one from Example 24 were reacted with Lawesson's reagent in analogy to Example 20. The crude product after concentration was chromatographed (silica gel; ethyl acetate/heptane=1:1). 30 mg (28%) of the desired compound, of melting point 203°-204° C., were obtained.

Fuente