Reacción #49803

Ecuación de reacción

water

Benzyl alcohol

triethylamine

{o-[5-(2,4-dichlorophenoxy)-2-nitrophenoxy]phenoxy}acetyl chloride

→

title product

Rendimiento 77.8%

Benzyl {o-[5-(2,4-dichlorophenoxy)-2-nitrophenoxy]phenoxy}acetate

Rendimiento 77.8%

Disolventes

tetrahydrofuran

—

hexanes

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with ether
2. 2
   LavadoThe combined organic extracts are washed sequentially with one molar hydrochloric acid, water and brine
3. 3
   Secadodried over anhydrous magnesium sulfate
4. 4
   Concentraciónconcentrated in vacuo
5. 5
   Otroto obtain an oil

Procedimiento

Benzyl alcohol (0.8 mL, 7.73 mmol) and triethylamine (1 mL, 7.17 mmol) are added to a mixture of {o-[5-(2,4-dichlorophenoxy)-2-nitrophenoxy]phenoxy}acetyl chloride (1.12 g, 2.38 mmol) in tetrahydrofuran. The reaction mixture is stirred for twenty minutes, poured into water and extracted with ether. The combined organic extracts are washed sequentially with one molar hydrochloric acid, water and brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to obtain an oil. Column chromatography of the oil using silica gel and a hexanes in methylene chloride solution gives the title product as a yellow oil (1.0 g) which is identified by NMR spectral analyses.

Fuente