Reacción #496424

ord-2c17db980c324328b4971c48ab1cd9ec

Ecuación de reacción

COC(=O)c1nc(C#N)c2c(Oc3ccccc3OC)cccc2c1O
1-cyano-4-hydroxy-8-(2-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester
NCC(=O)O
glycine
→
COc1ccccc1Oc1cccc2c(O)c(C(=O)NCC(=O)O)nc(C#N)c12
title compound
COc1ccccc1Oc1cccc2c(O)c(C(=O)NCC(=O)O)nc(C#N)c12
{[1-Cyano-4-hydroxy-8-(2-methoxy-phenoxy)-isoquinoline-3-carbonyl]-amino}-acetic acid

Reactantes

COC(=O)c1nc(C#N)c2c(Oc3ccccc3OC)cccc2c1O
1-cyano-4-hydroxy-8-(2-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester
NCC(=O)O
glycine

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The title compound was synthesized from 1-cyano-4-hydroxy-8-(2-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester and glycine in analogy to example 1b; MS-(−)-ion: M−1=392.5.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08759373B2uspto-grants-2014_06