Reacción #496417

ord-97d4068202c548048f04ee968669497a

Ecuación de reacción

COC(=O)c1nc(Br)c2c(Oc3ccc(OC)cc3)cccc2c1O
1-bromo-4-hydroxy-8-(4-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester
N#[C][Cu]
CuCN
→
COC(=O)c1nc(C#N)c2c(Oc3ccc(OC)cc3)cccc2c1O
title compound
COC(=O)c1nc(C#N)c2c(Oc3ccc(OC)cc3)cccc2c1O
1-Cyano-4-hydroxy-8-(4-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester

Reactantes

COC(=O)c1nc(Br)c2c(Oc3ccc(OC)cc3)cccc2c1O
1-bromo-4-hydroxy-8-(4-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester
N#[C][Cu]
CuCN

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The title compound was synthesized from 1-bromo-4-hydroxy-8-(4-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester and CuCN in analogy to example 3a; MS-(+)-ion: M+1=351.4.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08759373B2uspto-grants-2014_06