Reacción #49600

Ecuación de reacción

4-chloro-5-hydroxy-7-iodoisoindolinone

potassium carbonate

(4-bromo-2-methyl-2-butoxy)triethylsilane

→

4-chloro-5-[3-methyl-3-(triethylsiloxy)butoxy]-7-iodoisoindolinone

Rendimiento 35.0%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrofollowed by purification by flash column chromatography (chloroform/methanol=99/1)

Procedimiento

In a similar manner to Step 1 of Example 429, 4-chloro-5-hydroxy-7-iodoisoindolinone (70.8 mg, 0.229 mmol) was dissolved in DMF (2.1 mL), and the solution was treated with potassium carbonate (94.8 mg, 0.686 mmol), tetrabutylammonium iodide (8.5 mg, 0.023 mmol) and (4-bromo-2-methyl-2-butoxy)triethylsilane (193 mg, 0.686 mmol), followed by purification by flash column chromatography (chloroform/methanol=99/1) to obtain 4-chloro-5-[3-methyl-3-(triethylsiloxy)butoxy]-7-iodoisoindolinone (40.7 mg, yield 35%).

Fuente