Reacción #49547

Ecuación de reacción

3-methoxymethoxy-4-methoxy-N-(1-methyl-1-phenylethyl)benzamide

TMEDA

DMF

→

4-methoxymethoxy-5-methoxy-3-hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone

Rendimiento 79.0%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrofollowed by purification by slurry

Procedimiento

In a similar manner to Step 2 of Example 16, 3-methoxymethoxy-4-methoxy-N-(1-methyl-1-phenylethyl)benzamide (7.50 g, 22.8 mmol) was dissolved in THF (200-mL), and the solution was treated with TMEDA (11.0 mL, 72.9 mmol), sec-butyl lithium-hexane solution (0.95 mol/L, 77.0 mL, 73.2 mmol) and DMF (3.88 mL, 50.1 mmol), followed by purification by slurry using isopropylether and hexane to obtain 4-methoxymethoxy-5-methoxy-3-hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone (6.41 g, yield 79%).

Fuente