Reacción #49537

Ecuación de reacción

4-chloro-5-methoxymethoxy-3-hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone

TMEDA

iodine

→

4-chloro-5-methoxymethoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone

Rendimiento 96.1%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrofollowed by purification by slurry

Procedimiento

In a similar manner to Step 3 of Example 16, 4-chloro-5-methoxymethoxy-3-hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone (3.01 g, 8.32 mmol) was dissolved in THF (110 mL), and the solution was treated with TMEDA (4.00 mL, 26.5 mmol), sec-butyl lithium-hexane solution (0.95 mol/L, 28.0 mL, 26.6 mmol) and iodine (2.53 g, 9.98 mmol), followed by purification by slurry using diisopropylether to obtain 4-chloro-5-methoxymethoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (3.90 g, yield 96%).

Fuente