Reacción #495359

Ecuación de reacción

Water

NaH

4-chloro-5-iodo-1H-pyrrolo[2,3-b]pyridine

Benzenesulfonyl chloride

→

4-chloro-5-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Rendimiento 98.0%

Disolventes

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGthe reaction was stirred at room temperature for 2 hours
2. 2
   workup.STIRRINGstirred for 10 minutes
3. 3
   OtroThe solid formed
4. 4
   Filtraciónwas collected by filtration
5. 5
   Lavadowashed with ether
6. 6
   Otrodried

Procedimiento

NaH (0.960 g, 24.0 mmol, 60% dispersion in mineral oil) at 0° C. was added to 4-chloro-5-iodo-1H-pyrrolo[2,3-b]pyridine (5.57 g, 20.0 mmol) in dimethylformamide (“DMF”; 40 mL) and stirred at 0° C. for 20 minutes. Benzenesulfonyl chloride (2.82 mL, 22.0 mmol) was added, and the reaction was stirred at room temperature for 2 hours. Water (200 mL) was added and stirred for 10 minutes. The solid formed was collected by filtration, washed with ether, and dried to give 4-chloro-5-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (8.20 g, 98% yield).

Fuente