Reacción #49525

Ecuación de reacción

3-chloro-4-methylbenzoic acid

EDCI

HOBT monohydrate

cumylamine

→

3-chloro-4-methyl-N-(1-methyl-1-phenylethyl)benzamide

Rendimiento 97.2%

Disolventes

water

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe precipitated solid was collected by filtration
2. 2
   Lavadowashed with water
3. 3
   Otroby drying under reduced pressure
4. 4
   OtroThe obtained solid was purified by slurry

Procedimiento

In a similar manner to Step 1 of Example 137, 3-chloro-4-methylbenzoic acid (1.00 g, 5.86 mmol) was dissolved in DMF (20 mL), and the solution was treated with EDCI (2.25 g, 11.7 mmol), HOBT monohydrate (792 mg, 5.86 mmol) and cumylamine (1.69 mL, 11.7 mmol). The reaction mixture was added with water. The precipitated solid was collected by filtration and washed with water, followed by drying under reduced pressure. The obtained solid was purified by slurry using diisopropylether to obtain 3-chloro-4-methyl-N-(1-methyl-1-phenylethyl)benzamide (1.64 g, yield 97%).

Fuente