Reacción #495241

Ecuación de reacción

Metformin hydrochloride

metformin hydrochloride

magnesium stearate

→

Metformin

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrodried in the same device
2. 2
   OtroDried granulate
3. 3
   OtroObtained granulate
4. 4
   Otrois obtained

Procedimiento

Metformin hydrochloride is screened through 1 mm sieve. Screened metformin hydrochloride and hydroxypropylmethylcellulose are granulated in fluid bed granulator with demineralized water and dried in the same device. Dried granulate is screened through 1 mm sieve. Obtained granulate and microcrystalline cellulose are homogenously blended in a bin blender. Pre-sieved magnesium stearate is added to the obtained blend and blended in a bin blender so that the final blend is obtained.

Fuente