Reacción #49512

Ecuación de reacción

cumylamine

triethylamine

3,4-dichlorobenzoyl chloride

→

3,4-dichloro-N-(1-methyl-1-phenylethyl)benzamide

Rendimiento 88.0%

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrofollowed by purification by slurry

Procedimiento

In a similar manner to Step 1 of Example 16, 3,4-dichlorobenzoyl chloride (3.00 g, 14.3 mmol) was dissolved in dichloromethane (60 mL), and the solution was treated with cumylamine (2.30 mL, 15.7 mmol), triethylamine (3.00 mL, 21.5 mmol) and DMAP (175 mg, 1.43 mmol), followed by purification by slurry using chloroform to obtain 3,4-dichloro-N-(1-methyl-1-phenylethyl)benzamide (3.85 g, yield 88%).

Fuente