Reacción #49458
ord-3942dbaf31904f18b90500ed56858435
Ecuación de reacción
dimethylcarbamoyl chloride
4-hydroxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone
→
4-dimethylcarbamoyloxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone
Rendimiento 99.8%
Reactantes
Reactivos
Disolventes
Condiciones de reacción
Condiciones detalladas
See reaction.notes.procedure_details.
Procedimiento
In a similar manner to Step 1 of Example 227, 4-hydroxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0806 g, 0.175 mmol) was dissolved in dichloromethane (2.0 mL), and the solution was treated with 4-dimethylaminopyridine (0.0850 g, 0.699 mmol) and dimethylcarbamoyl chloride (0.0640 mL, 0.699 mmol) to obtain 4-dimethylcarbamoyloxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0930 g, yield 99%).