Reacción #49410

Ecuación de reacción

4-Ethenesulfonyloxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone

ethylamine

→

4-[2-(ethylamino)ethanesulfonyloxy]-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone

Rendimiento 43.0%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was evaporated under reduced pressure
2. 2
   Otrothe residue was purified by thin-layer chromatography (chloroform/methanol=6/1)

Procedimiento

4-Ethenesulfonyloxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0734 g, 0.133 mmol) was dissolved in methanol (1.5 mL), and the solution was added with 70% aqueous ethylamine solution (1.5 mL), followed by stirring at room temperature for 5 hours. The solvent was evaporated under reduced pressure and the residue was purified by thin-layer chromatography (chloroform/methanol=6/1) to obtain 4-[2-(ethylamino)ethanesulfonyloxy]-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0338 g, 43%).

Fuente