Reacción #49374

Ecuación de reacción

7-amino-4-(thiophen-2-yl)isoindolinone

potassium iodide

iodine

tert-butyl nitrite

→

7-iodo-4-(thiophen-2-yl)isoindolinone

Rendimiento 44.0%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrofollowed by purification by preparative thin-layer chromatography (chloroform/acetonitrile-6/1, chloroform/methanol=10/1)

Procedimiento

In a similar manner to Step 4 of Example 140, 7-amino-4-(thiophen-2-yl)isoindolinone (212 mg, 0.920 mmol) was dissolved in acetonitrile (14.8 mL), and the solution was treated with potassium iodide (183 mg, 1.10 mmol), copper iodide (210 mg, 1.10 mmol), iodine (280 mg, 1.10 mmol) and tert-butyl nitrite (0.382 mL, 2.76 mmol), followed by purification by preparative thin-layer chromatography (chloroform/acetonitrile-6/1, chloroform/methanol=10/1) to obtain 7-iodo-4-(thiophen-2-yl)isoindolinone (138 mg, yield 44%).

Fuente