Reacción #49371

Ecuación de reacción

7-amino-4-(furan-2-yl)isoindolinone

potassium iodide

iodine

tert-butyl nitrite

→

7-iodo-4-(furan-2-yl)isoindolinone

Rendimiento 58.0%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrofollowed by purification by preparative thin-layer chromatography (chloroform/acetonitrile=6/1)

Procedimiento

In a similar manner to Step 4 of Example 140, 7-amino-4-(furan-2-yl)isoindolinone (43.0 mg, 0.201 mmol) was dissolved in acetonitrile (4.3 mL), and the solution was treated with potassium iodide (40.0 mg, 0.241 mmol), copper iodide (46.0 mg, 0.241 mmol), iodine (61.0 mg, 0.241 mmol) and tert-butyl nitrite (0.072 mL, 0.60 mmol), followed by purification by preparative thin-layer chromatography (chloroform/acetonitrile=6/1) to obtain 7-iodo-4-(furan-2-yl)isoindolinone (37.8 mg, yield 58%).

Fuente