Reacción #49314

ord-8a095a3be3454122832f315b652ab987

Disolventes

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

In a similar manner to Step 1 of Example 56, 4-chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone (20.0 mg, 0.0487 mmol) was dissolved in dichloromethane (0.5 mL), and the solution was treated with 2-amino-1 propanol (0.0080 mL, 0.10 mmol) and sodium triacetoxyborohydride (32 mg, 0.15 mmol) to obtain 4-chloro-7-{1-(tert-butoxycarbonyl)-5-[(2-hydroxy-1-methylethyl)aminomethyl]indol-2-yl}isoindolinone.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07745641B2uspto-grants-2010_06