Reacción #492

Ecuación de reacción

COC(=O)c1cc(Br)cc(C(

C1COCCN1

→

COC(=O)c1cc(C(=O)OC)

Rendimiento 78.2%

Disolventes

Cc1ccccc1

Condiciones de reacción

Procedimiento

To a solution of dimethyl 5-bromoisophthalate (10 g, 36.62 mmol) in toluene (100 mL) where BINAP (2.5 g, 4.01 mmol), morpholine (4.4 g, 50.50 mmol), CESIUM CARBONATE (18 g, 55.25 mmol) and PALLADIUM(II) ACETATE (0.9 g, 4.01 mmol) added. The solution was heated to reflux under inert atm for 14h. The silvent was filtered and the filtrate was concentrated. The residue was purified by column chropmatography (Hep:EA) 1:1 to give dimethyl 5-morpholinoisophthalate (8.00 g, 78 %)

Fuente