Reacción #49199

Ecuación de reacción

lithium borohydride

ethyl ester

4-Hydroxy-pyrrolidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester

→

3-Hydroxy-4-hydroxymethyl-pyrrolidine-1-carboxylic acid benzyl ester

Disolventes

tetrahydrofuran

THF

MeOH CHCl3

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONAfter the addition the reaction mixture
2. 2
   Otrowas brought to room temperature
3. 3
   OtroThe reaction mixture was evaporated to dryness
4. 4
   workup.ADDITIONTo the residue 3N HCl (40 mL) was added slowly
5. 5
   workup.STIRRINGAfter stirring for 30 mins the product
6. 6
   Extracciónwas extracted with dichloromethane (3×75 mL)
7. 7
   LavadoThe combined organic layer was washed with brine
8. 8
   Secadodried over sodium sulfate
9. 9
   FiltraciónOrganic layer was filtered
10. 10
    Otroevaporated to dryness
11. 11
    OtroCompound 74 was purified by column chromatography first
12. 12
    Lavadoby eluting with dichloromethane/methanol (5%) (1.98 g, 85%)

Procedimiento

To the solution of lithium borohydride (0.305 g, 13 mmol) in anhydrous tetrahydrofuran (25 mL) was added a solution of ethyl ester 73 (2.69 g, 9.2 mmol) in THF (25 mL) over a period of 30 mins at 0° C. After the addition the reaction mixture was brought to room temperature and stirred further under argon. The completion of the reaction was ascertained by TLC after 4 h. (Rf=0.3 in 10% MeOH/CHCl3). The reaction mixture was evaporated to dryness and cooled to 0° C. To the residue 3N HCl (40 mL) was added slowly. After stirring for 30 mins the product was extracted with dichloromethane (3×75 mL). The combined organic layer was washed with brine and dried over sodium sulfate. Organic layer was filtered and evaporated to dryness. Compound 74 was purified by column chromatography first by eluting with dichloromethane/methanol (5%) (1.98 g, 85%).

Fuente