Reacción #4908

Ecuación de reacción

2-[(1-methyl-3-pyrrolidinyl)thio]-3-pyridinecarboxylic acid

chloroform

triphenylphosphine

→

2-(2-Chloroethyl)-2,3-dihydro-4-methylpyrido[3,2-f][1,4]-thiazepin-5(4H)-one

Disolventes

carbon tetrachloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux for 2.5 hr
2. 2
   ExtracciónThe resulting solution was extracted with one 500 ml and three 125 ml portions of 1N hydrochloric acid
3. 3
   Extracciónextracted with isopropyl ether
4. 4
   Extracciónextracted three times with chloroform
5. 5
   ExtracciónThe combined chloroform extract
6. 6
   Secadowas dried over sodium sulfate
7. 7
   Concentraciónconcentrated
8. 8
   OtroA portion of the residue was chromatographed on the high pressure liquid chromatograph
9. 9
   OtroThe compound obtained
10. 10
    Otrowas crystallized from isopropyl ether-isopropyl alcohol, m.p. 97°-100° C.

Procedimiento

A mixture of 80.75 g (0.34 mole) of 2-[(1-methyl-3-pyrrolidinyl)thio]-3-pyridinecarboxylic acid, 500 ml of chloroform, 200 g of carbon tetrachloride and 178 g (0.68 mole) of triphenylphosphine was stirred at reflux for 2.5 hr. The resulting solution was extracted with one 500 ml and three 125 ml portions of 1N hydrochloric acid. The acid extracts were combined and extracted with isopropyl ether. The aqueous layer was basified with sodium hydroxide and extracted three times with chloroform. The combined chloroform extract was dried over sodium sulfate and concentrated. A portion of the residue was chromatographed on the high pressure liquid chromatograph using a silica column and ethyl acetate. The compound obtained was crystallized from isopropyl ether-isopropyl alcohol, m.p. 97°-100° C.

Fuente