Reacción #49062

Ecuación de reacción

dimethylamine hydrochloride

cyclopentanone

potassium cyanide

→

title product

Rendimiento 96.5%

1-(Dimethylamino)cyclopentanecarbonitrile

Rendimiento 96.5%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaTo a stirred, ice cooled
2. 2
   ExtracciónThen, the mixture was extracted into diethylether (2×200 ml)
3. 3
   Lavadothe combined organics were washed with brine (200 ml)
4. 4
   Secadodried (Na2SO4)
5. 5
   Otroevaporated in vacuo

Procedimiento

To a stirred, ice cooled mixture of dimethylamine hydrochloride (26.32.g; 0.323 mol) and cyclopentanone (27.15 g; 0.323 mol) was added dropwise a solution of potassium cyanide (21.02 g; 0.323 mol) in water (170 ml) over 10 min. The mixture was stirred at room temperature overnight. Then, the mixture was extracted into diethylether (2×200 ml) and the combined organics were washed with brine (200 ml), dried (Na2SO4), and evaporated in vacuo to afford the title product as a colourless liquid (43 g, 96.5%)

Fuente