Reacción #48920

Ecuación de reacción

4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one

Selectfluor

→

4-amino-8-(cyclopentyloxy)-3-fluoro-7-methoxy-2H-chromen-2-one

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   Concentraciónconcentrated
2. 2
   Otropurified by silica gel chromatography (7:3→1:4; hexanes:ethyl acetate)

Procedimiento

A mixture of 4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one (100 mg, 0.36 mmol, Example 3, Step 1), Selectfluor (160 mg, 0.45 mmol), and acetonitrile (1.5 mL) were stirred vigorously for 18 h, concentrated, and then purified by silica gel chromatography (7:3→1:4; hexanes:ethyl acetate) to give 4-amino-8-(cyclopentyloxy)-3-fluoro-7-methoxy-2H-chromen-2-one: MS (ESI): 294.0.

Fuente