Reacción #48873

Ecuación de reacción

3-(4-acetylphenoxy)-5-[(1S)-2-methoxy-1-methylethoxy]-N-(1′-methyl-1H-pyrazol-3-yl)benzamide

N,N-dimethylformamide dimethyl acetal

→

desired product

Rendimiento 83.3%

3-{-4-[(2E)-3-(Dimethylamino)prop-2-enoyl]phenoxy}-5-[(1S)-2-methoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

Rendimiento 83.3%

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe volatiles were removed under reduced pressure
2. 2
   Otrothe resulting oil purified by chromatography on silica
3. 3
   Lavadoeluting with 0-20% methanol in DCM

Procedimiento

A mixture of 3-(4-acetylphenoxy)-5-[(1S)-2-methoxy-1-methylethoxy]-N-(1′-methyl-1H-pyrazol-3-yl)benzamide (812 mg, 1.92 mmol) and N,N-dimethylformamide dimethyl acetal (10.2 mL, 77 mmol) was heated to 100° C. in a ‘Smith Creator’ microwave for 140 mins. The volatiles were removed under reduced pressure and the resulting oil purified by chromatography on silica, eluting with 0-20% methanol in DCM, to give the desired product (765 mg).

Fuente