Reacción #48862

Ecuación de reacción

Azetidine

4-fluorobenzenesulfonyl chloride

→

solid

Rendimiento 8.0%

1-[(4-Fluorophenyl)sulfonyl]azetidine

Rendimiento 8.0%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroreaction mixture
2. 2
   ConcentraciónThe reaction mixture was concentrated in vacuo
3. 3
   OtroThe organic layer was separated
4. 4
   Secadodried (MgSO4)
5. 5
   Filtraciónfiltered
6. 6
   Otroevaporated

Procedimiento

Azetidine (0.25 g, 4.35 mmol) was added to a solution of sodium hexamethyldisilylazide (0.85 g, 4.6 mmol) in THF (10 mL) at 0° C. and reaction mixture stirred for 10 minutes. 4-fluorobenzenesulfonyl chloride (0.85 g, 4.35 mmol) was subsequently added and the reaction mixture was allowed to warm up to ambient temperature overnight. The reaction mixture was concentrated in vacuo and the residue taken up in ethyl acetate and water. The organic layer was separated and then dried (MgSO4), filtered and evaporated to give a waxy, yellow solid (75 mg).

Fuente