Reacción #48838

Ecuación de reacción

ethyl 4-(3-[(1S)-2-hydroxy-1-methylethoxy]-5-{[(5-methylpyrazin-2-yl)amino]carbonyl}phenoxy)benzoate

lithium hydroxide monohydrate

→

desired compound

Rendimiento 59.0%

4-(3-[(1S)-2-Hydroxy-1-methylethoxy]-5-{[(5-methylpyrazin-2-yl)amino]carbonyl}phenoxy)benzoic acid

Rendimiento 59.0%

Disolventes

THF

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe THF removed in vacuo
2. 2
   Filtraciónthe solid precipitate filtered off
3. 3
   Lavadowashed with water
4. 4
   Otrodried in vacuo

Procedimiento

A solution of ethyl 4-(3-[(1S)-2-hydroxy-1-methylethoxy]-5-{[(5-methylpyrazin-2-yl)amino]carbonyl}phenoxy)benzoate (0.4 g, 0.88 mmol) in THF (16 mL) was added to a solution of lithium hydroxide monohydrate (0.19 g, 4.43 mmol) in water (8 mL). The mixture was stirred at RT for 72 hours and the THF removed in vacuo. The aqueous layer was acidified with 1M hydrochloric acid (10 mL), and the solid precipitate filtered off, washed with water and dried in vacuo to give the desired compound (0.22 g). The material was used without further purification.

Fuente