Reacción #48830

Ecuación de reacción

2-Chloro-4,5-difluorobenzenesulfonyl chloride

sodium sulfite

sodium bicarbonate

bromoacetic acid

→

desired compound

Rendimiento 48.0%

1-Chloro-4,5-difluoro-2-(methylsulfonyl)benzene

Rendimiento 48.0%

Disolventes

water

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato cool
2. 2
   Temperaturaheated to 150° C. for 300 seconds
3. 3
   Temperaturato cool
4. 4
   Otrowas removed by filtration
5. 5
   Otrodried in vacuo

Procedimiento

2-Chloro-4,5-difluorobenzenesulfonyl chloride (300 mg) was added to a solution of sodium sulfite (306 mg) and sodium bicarbonate (153 mg) in water (4 mL). The mixture was heated to 150° C. in a sealed microwave vial for 400 seconds and allowed to cool. The mixture was treated with bromoacetic acid (253 mg) in water (1 mL), and heated to 150° C. for 300 seconds then allowed to cool, following which the precipitate was removed by filtration and dried in vacuo to give the desired compound (132 mg). The material was used without further purification.

Fuente