Reacción #48822

Ecuación de reacción

3-hydroxy-5-[(1S)-2-methoxy-(1-methylethyl)oxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

potassium carbonate

3-chloro-4-fluoro-N,N-dimethylbenzenesulfonamide

→

title compound

3-{2-Chloro-4-[(dimethylamino)sulfonyl]phenoxy}-5-[(1S)-2-methoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe mixtures were filtered
2. 2
   Otroevaporated
3. 3
   OtroThe residue was purified by flash chromatography (
4. 4
   Lavadoeluting with an increasing gradient of 60 to 100% ethyl acetate in isohexane)

Procedimiento

To a solution of 3-hydroxy-5-[(1S)-2-methoxy-(1-methylethyl)oxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide (152 mg, 0.50 mmol) in acetonitrile (3.5 mL) was added potassium carbonate (345 mg, 2.5 mmol) and 3-chloro-4-fluoro-N,N-dimethylbenzenesulfonamide (237 mg, 1.0 mmol) and the mixture was heated under microwave conditions at 160° C. for 2 hours. The mixtures were filtered and evaporated. The residue was purified by flash chromatography (eluting with an increasing gradient of 60 to 100% ethyl acetate in isohexane) to afford the title compound (1.8 g, 98%).

Fuente