Reacción #48816

Ecuación de reacción

3-(benzyloxy)-5-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-N-(1-isopropyl-1H-pyrazol-3-yl)benzamide

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product

Rendimiento 97.0%

3-((1S)-2-{[tert-Butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-hydroxy-N-(1-isopropyl-1H-pyrazol-3-yl)benzamide

Rendimiento 97.0%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   Otropurged with, Argon (×3)
2. 2
   workup.ADDITIONPalladium on carbon (10% w/w, 400 mg) was added
3. 3
   Otroreaction mixture
4. 4
   Otrowas evacuated
5. 5
   Otrofinally purged with hydrogen gas
6. 6
   OtroReaction mixture
7. 7
   workup.WAITwas left
8. 8
   FiltraciónPd/C was filtered off
9. 9
   Concentraciónconcentrated in vacuo

Procedimiento

A solution of 3-(benzyloxy)-5-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-N-(1-isopropyl-1H-pyrazol-3-yl)benzamide (1.97 g, 3.77 mmol) and THF (70 mL) was evacuated and purged with, Argon (×3). Palladium on carbon (10% w/w, 400 mg) was added and reaction mixture was evacuated and finally purged with hydrogen gas. Reaction mixture was left to stir at ambient temperature under hydrogen for 16 hours. Pd/C was filtered off and concentrated in vacuo to give the product as a colourless oil (1.58 g, 97%).

Fuente