Reacción #487543

Ecuación de reacción

2,4-dichloro-6-(2,2,2-trifluoroethoxy)-1,3,5-triazine

methyl 4-amino-2-(3-chloropropoxy)benzoate

→

methyl 4-(4-chloro-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)-2-(3-chloropropoxy)benzoate

Disolventes

THF

DCM

water

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe organic layer was collected
2. 2
   Secadodried over sodium sulfate
3. 3
   Concentraciónconcentrated under vacuum
4. 4
   OtroThe crude product was purified by silica gel chromatography
5. 5
   OtroThe product fractions were collected
6. 6
   Concentraciónconcentrated under vacuum

Procedimiento

To a solution of 2,4-dichloro-6-(2,2,2-trifluoroethoxy)-1,3,5-triazine (770 mg, 2.79 mmol) in THF (10 mL) was added methyl 4-amino-2-(3-chloropropoxy)benzoate (681 mg, 2.79 mmol) and Hunig'sBase (1.464 mL, 8.38 mmol). The resulting mixture was stirred for 16 h. The reaction was diluted with DCM and water. The organic layer was collected and dried over sodium sulfate, and concentrated under vacuum. The crude product was purified by silica gel chromatography using 20-40% EtOAc/Hexanes. The product fractions were collected and concentrated under vacuum to give methyl 4-(4-chloro-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)-2-(3-chloropropoxy)benzoate as a solid.

Fuente