Reacción #487538

Ecuación de reacción

water

N,O-dimethylhydroxyamine hydrochloride

Decanoic acid

→

N-methoxy-N-methyldecanamide

Rendimiento 97.0%

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas then added to the solution
2. 2
   workup.STIRRINGthe obtained mixture was further stirred for 3 hours
3. 3
   Extracciónthe reaction solution was extracted with dichloromethane two times
4. 4
   workup.ADDITIONAnhydrous magnesium sulfate was added to the organic layer
5. 5
   Otroto dry it
6. 6
   Filtraciónthe resultant was filtrated
7. 7
   Concentraciónwas then concentrated
8. 8
   OtroThe obtained residue was purified

Procedimiento

Decanoic acid (4 g, 23.2 mmol) was dissolved in an anhydrous dichloromethane solution (80 mL), and 1,1-carbonyldiimidazole (4.5 g, 27.9 mmol) was then added to the solution, followed by stirring for 1.5 hours. Subsequently, N,O-dimethylhydroxyamine hydrochloride (2.7 g, 27.9 mmol) was added to the reaction solution, and the obtained mixture was further stirred for 3 hours. After addition of distilled water, the reaction solution was extracted with dichloromethane two times. Anhydrous magnesium sulfate was added to the organic layer to dry it, and the resultant was filtrated and was then concentrated. The obtained residue was purified using column chromatography (hexane:ethyl acetate=8:1), so as to obtain N-methoxy-N-methyldecanamide (4.8 g, 97%) as an amide body in the form of a colorless transparent liquid.

Fuente