Reacción #48689

Ecuación de reacción

trifluoromethanesulphonic anhydride

neopentylalcohol

2,6-lutidine

→

desired compound

Rendimiento 72.0%

Trifluoromethanesulfonic acid 2,2-dimethylpropyl ester

Rendimiento 72.0%

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAdd water to quench
2. 2
   Otrothe reaction
3. 3
   Otroseparate the organic layer
4. 4
   Extracciónextract the aqueous layer with dichloromethane
5. 5
   Secadodry (magnesium sulfate)
6. 6
   Filtraciónfilter
7. 7
   Concentraciónconcentrate
8. 8
   Otropurify
9. 9
   Lavado(silica gel chromatography, eluting with 1:4 hexane:dichloromethane)

Procedimiento

Add trifluoromethanesulphonic anhydride (1.12 mL, 6.8 mmol) to a solution of neopentylalcohol (0.5 g, 5.7 mmol) and 2,6-lutidine (0.7 mL, 6.8 mmol) in dichloromethane (10 mL) at −78° C. and stir for 1 hour. Add water to quench the reaction, separate the organic layer and extract the aqueous layer with dichloromethane. Combine the organic layers, dry (magnesium sulfate), filter, concentrate and purify (silica gel chromatography, eluting with 1:4 hexane:dichloromethane) to give the desired compound as an oil (0.9 g, 72% yield).

Fuente