Reacción #48664

Ecuación de reacción

ethyl acetate

polypropylene

1,6-dioxaspiro[2,5]octane-2-carbonitrile

hydrogen fluoride-pyridine

→

desired compound

(4-Fluorotetrahydropyran-4-yl)-hydroxyacetonitrile

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowash with saturated aqueous sodium bicarbonate solution until washes
2. 2
   Extracciónextract with ethyl acetate
3. 3
   ExtracciónCombine this organic extract with the ethyl acetate solution of the crude
4. 4
   Otroreaction mixture
5. 5
   Lavadowash with saturated aqueous sodium chloride solution
6. 6
   Secadodry (magnesium sulfate)
7. 7
   Filtraciónfilter
8. 8
   Concentraciónconcentrate

Procedimiento

Dissolve 1,6-dioxaspiro[2,5]octane-2-carbonitrile (4.14 g, 29.8 mmol) in dry dichloromethane (10 mL) and cool to 0° C. under a nitrogen atmosphere in a polypropylene bottle. Add hydrogen fluoride-pyridine (3 mL) dropwise. Allow the mixture to slowly warm to room temperature over 3 h and then stir an additional 1.5 hours at room temperature. Pour into ethyl acetate and wash with saturated aqueous sodium bicarbonate solution until washes remain basic. Combine the aqueous washes and adjust the pH of the solution to ˜pH=8 and extract with ethyl acetate. Combine this organic extract with the ethyl acetate solution of the crude reaction mixture and wash with saturated aqueous sodium chloride solution, dry (magnesium sulfate), filter and concentrate to give the desired compound as a yellow oil which is used directly in the next reaction.

Fuente