Reacción #48519

Ecuación de reacción

benzyl 4-oxopiperidin-1-carboxylate

β-alanine methyl ester monohydrochloride

acetic acid

sodium triacetoxyborohydride

→

title compound

Rendimiento 87.4%

Benzyl 4-[(3-methoxy-3-oxopropyl)amino]piperidin-1-carboxylate

Rendimiento 87.4%

Disolventes

dichloroethane

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoThe reaction mixture was washed with aqueous saturated sodium bicarbonate solution and saturated saline solution
2. 2
   Secadodried over anhydrous sodium sulfate
3. 3
   Concentraciónconcentrated under reduced pressure

Procedimiento

A solution of benzyl 4-oxopiperidin-1-carboxylate (10 g), β-alanine methyl ester monohydrochloride (5.99 g), acetic acid (4 mL) and sodium triacetoxyborohydride (10.9 g) in dichloroethane (400 mL) was stirred overnight. The reaction mixture was washed with aqueous saturated sodium bicarbonate solution and saturated saline solution, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain the title compound (12.0 g, 87%) as a colorless oil.

Fuente