Reacción #48366

Ecuación de reacción

2-Amino-6-methoxy-3-nitropyridine

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title compound

2,3-Diamino-6-methoxypyridine

Disolventes

methanol ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe solution was cooled
2. 2
   Otropurged with argon, and 10% palladium on carbon
3. 3
   workup.ADDITIONwas added (0.45 g)
4. 4
   workup.ADDITIONHydrogen was introduced (1 atm)
5. 5
   FiltraciónThe catalyst was filtered
6. 6
   Otrothe solvent evaporated from the filtrate

Procedimiento

2-Amino-6-methoxy-3-nitropyridine (2.8 g, 16.5 mmol) was dissolved in warm 1:1 methanol/ethanol (200 mL). The solution was cooled, purged with argon, and 10% palladium on carbon was added (0.45 g). Hydrogen was introduced (1 atm) and the reaction stirred until complete. The catalyst was filtered and the solvent evaporated from the filtrate to give the title compound. MS 140 (M+1) 1H NMR (500 MHz, CDCl3) δ 6.93 (d, J=8 Hz, 1H), 6.04 (d, J=8 Hz, 1H), 4.15 (br s, 2H), 3.80 (s, 3H), 3.0 (br s, 2H).

Fuente