Reacción #483123

Ecuación de reacción

bromine

4′-octylacetophenone

hydrogen bromide acetic acid

→

2-bromo-4′-octylacetophenone

Disolventes

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturacooling
2. 2
   workup.DISTILLATIONThe solvent is distilled away
3. 3
   Otrothe mixture is purified by silica gel column chromatography

Procedimiento

To a solution of 4′-octylacetophenone (18′) (23.9 g) in acetic acid (100 ml) is added hydrogen bromide-acetic acid solution (25%, 34 ml) under ice-cooling, which is followed by dropwise addition of bromine (5.3 ml). The mixture is heated to 30° C. and stirred for 3 hr. The solvent is distilled away and the mixture is purified by silica gel column chromatography to give 2-bromo-4′-octylacetophenone as colorless crystals.

Fuente