Reacción #48263

Ecuación de reacción

Potassium carbonate

3,4-dihydroxybenzoic acid methyl ester

benzyl bromide

→

3,4-Dibenzyloxy benzoic acid methyl ester

Rendimiento 122.9%

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture was refluxed for 12 hrs
2. 2
   OtroAfter the removal of the solvent under reduced pressure
3. 3
   Otrothe residue was partitioned between ethyl acetate (150 ml) and water (50 ml)
4. 4
   LavadoThe ethyl acetate layer was washed with water (50 ml)
5. 5
   Secadodried over anhydrous magnesium sulfate
6. 6
   OtroRemoval of the solvent under reduced pressure

Procedimiento

Potassium carbonate (6.5 g; 47 mmol) was added to a solution of 3,4-dihydroxybenzoic acid methyl ester (2.6 g; 15.7 mmol) and benzyl bromide (5.37 g; 31.4 mmol) in acetone (100 ml). The reaction mixture was refluxed for 12 hrs. After the removal of the solvent under reduced pressure, the residue was partitioned between ethyl acetate (150 ml) and water (50 ml). The ethyl acetate layer was washed with water (50 ml) and dried over anhydrous magnesium sulfate. Removal of the solvent under reduced pressure provided 3.36 g of 3,4-Dibenzyloxy benzoic acid methyl ester (Yield=86.6%)

Fuente