Reacción #48260

Ecuación de reacción

Potassium carbonate

3,4-dihydroxy-1-nitrobenzene

benzyl bromide

→

3,4-Dibenzyloxy-1-nitro benzene

Rendimiento 141.3%

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture was refluxed for 12 hours
2. 2
   OtroAfter the removal of the solvent under reduced pressure
3. 3
   Otrothe residue was partitioned between ethyl acetate (150 ml) and water (50 ml)
4. 4
   LavadoThe ethyl acetate layer was washed with water (100 ml)
5. 5
   Secadodried over anhydrous magnesium sulfate
6. 6
   OtroRemoval of the solvent under reduced pressure

Procedimiento

Potassium carbonate (4.14 g; 30 mmol) was added to a solution of 3,4-dihydroxy-1-nitrobenzene (1.55 g; 10 mmol) and benzyl bromide (3.42 g; 20 mmol) in acetone (100 ml). The reaction mixture was refluxed for 12 hours. After the removal of the solvent under reduced pressure, the residue was partitioned between ethyl acetate (150 ml) and water (50 ml). The ethyl acetate layer was washed with water (100 ml) and dried over anhydrous magnesium sulfate. Removal of the solvent under reduced pressure provided 2.37 g of 3,4-Dibenzyloxy-1-nitro benzene. (Yield=70%)

Fuente