Reacción #48140

Ecuación de reacción

(4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone

(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone

intermediate 1

(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone

2-cyanopyridine-5-boronic acid pinacol ester

→

title compound

5-[2-(4,4-Difluoro-piperidine-1-carbonyl)-5-(1-isopropyl-piperidin-4-yloxy)-indol-1-yl]-pyridine-2-carbonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroIn analogy to the procedure described for the synthesis of example 6

Procedimiento

In analogy to the procedure described for the synthesis of example 6, the title compound was synthesized from (4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone (intermediate 1) and 2-cyanopyridine-5-boronic acid pinacol ester. The title compound was obtained in 51% yield as yellow foam. MS (m/e): 508.4 (MH+, 100%).

Fuente