Reacción #481224

ord-f399a6d66d554b8fab1b17afd16116f0

Ecuación de reacción

CCCCN1CCC[C@H](CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccccc2)(c2ccccc2)c2ccccc2)C1
(2R)-N-{((3R)-1-butyl-3-piperidyl)methyl}-1-{(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonylpyrrolidine-2-carboxamide
BrCC1CC1
(bromomethyl)cyclopropane
→
CCCC[N+]1(C)CCC[C@H](CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccccc2)(c2ccccc2)c2ccccc2)C1.[Br-]
title compound
CCCC[N+]1(C)CCC[C@H](CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccccc2)(c2ccccc2)c2ccccc2)C1.[Br-]
(3R)-1-butyl-3-({({(2R)-1-({(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)-2-pyrrolidinyl}carbonyl)-2-pyrrolidinyl}carbonyl)amino}methyl}-1-methylpiperidinium bromide

Reactantes

CCCCN1CCC[C@H](CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccccc2)(c2ccccc2)c2ccccc2)C1
(2R)-N-{((3R)-1-butyl-3-piperidyl)methyl}-1-{(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonylpyrrolidine-2-carboxamide
BrCC1CC1
(bromomethyl)cyclopropane

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroThe compound was obtained as a white foamy substance

Procedimiento

The title compound was prepared by a method similar to Example 128, using (2R)-N-{((3R)-1-butyl-3-piperidyl)methyl}-1-{(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonylpyrrolidine-2-carboxamide and (bromomethyl)cyclopropane. The compound was obtained as a white foamy substance.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06809108B1uspto-grants-2004_10