Reacción #481222

ord-4409fdbaf4f74090a95091fdbec6caca

Ecuación de reacción

O=C(NC[C@@H]1CCCN(CC2CC2)C1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1
(2R)-N-{((3S)-1-cyclopropylmethyl-3-piperidyl)methyl}-1-{(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonylpyrrolidine-2-carboxamide
BrCC1CC1
cyclopropylmethyl bromide
→
O=C(NC[C@@H]1CCC[N+](CC2CC2)(CC2CC2)C1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1.[Br-]
title compound
O=C(NC[C@@H]1CCC[N+](CC2CC2)(CC2CC2)C1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1.[Br-]
(3S)-1,1-dicyclopropylmethyl-3-({({(2R)-1-({(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)-2-pyrrolidinyl}carbonyl)-2-pyrrolidinyl}carbonyl)amino}methyl)piperidinium bromide

Reactantes

O=C(NC[C@@H]1CCCN(CC2CC2)C1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1
(2R)-N-{((3S)-1-cyclopropylmethyl-3-piperidyl)methyl}-1-{(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonylpyrrolidine-2-carboxamide
BrCC1CC1
cyclopropylmethyl bromide

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroThe compound was obtained as a white solid

Procedimiento

The title compound was prepared by a method similar to Example 130, using (2R)-N-{((3S)-1-cyclopropylmethyl-3-piperidyl)methyl}-1-{(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonylpyrrolidine-2-carboxamide and cyclopropylmethyl bromide. The compound was obtained as a white solid.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06809108B1uspto-grants-2004_10