Reacción #48077

Ecuación de reacción

H2O

2-(5-bromo-2-chlorophenyl)-propan-2-ol

p-toluenesulfonic acid

→

desired product

Rendimiento 77.1%

4-bromo-1-chloro-2-isopropenylbenzene

Rendimiento 77.1%

Disolventes

ether

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoThe mixture was washed with sat. NaHCO3-solution and brine
2. 2
   Secadodried (MgSO4)
3. 3
   Filtraciónfiltered
4. 4
   Concentraciónconcentrated in vacuo

Procedimiento

To a solution of 2-(5-bromo-2-chlorophenyl)-propan-2-ol (500 mg, 2 mmol, 1 eq) in toluene (5 ml) was added a catalytic amount of p-toluenesulfonic acid (38 mg, 0.2 mmol, 0.1 eq) and the solution was refluxed under a Dean-Stark H2O separator overnight. The reaction mixture was allowed to cool to RT and was diluted with ether. The mixture was washed with sat. NaHCO3-solution and brine, dried (MgSO4), filtered and concentrated in vacuo to give the desired product (357 mg, 77%) as a colorless oil which did not require further purification.

Fuente