Reacción #47891

Ecuación de reacción

1-(4-iodo-phenyl)-5-methoxy-pent-4-ene-1,3-dione

compound F1

1-(4-iodo-phenyl)-5-methoxy-pent-4-ene-1,3-dione

thiosemicarbazide

→

5-(4-Iodo-phenyl)-6H-pyrazolo[1,5-c]pyrimidine-7-thione

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturais heated
2. 2
   Temperaturato reflux temperature
3. 3
   Filtraciónis filtered
4. 4
   Lavadowashed with methanol
5. 5
   OtroThe filtrate with the product is purified by flash silica gel chromatography

Procedimiento

A mixture of 1-(4-iodo-phenyl)-5-methoxy-pent-4-ene-1,3-dione (compound F1)(1.9 g) and thiosemicarbazide (5 g) in methanol (220 ml) is heated to reflux temperature. After the reaction is completed the solid is filtered and washed with methanol. The filtrate with the product is purified by flash silica gel chromatography.

Fuente